Objectives

• Identify and categorise technologies offering prospects for efficiency gains outside incremental innovations (higher quality/higher costs)

• Clarify under which conditions decremental cost-effectiveness is acceptable for collective health gains

• Develop a tool-box for use at a local level for HTA projects to maximise those health gains

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Methodology

• Systematic search of clinical trials registries and published literature to identify decrementally cost-effective programmes, as for example non-drug interventions or non-inferiority trials

• Conduct a systematic enquiry into the willingness of stakeholders (namely patients, professionals, decision makers, tax payers) to accept a decremental efficacy

• A toolbox and guidance for HTA agencies to go beyond cost-effective comparators in their assessments and recommendations

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Outputs​

• Deliverable D11.1: Systematic review of decrementally cost-effective interventions [PDF]
   

• Deliverable D11.2: Stakeholders’ perspective: a political economy report [PDF]
   

• Deliverable D11.3: A toolbox on candidate cost-effective technologies for HTA producers and users [PDF]
   

• Work Package Overall Results [Poster PDF]

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Publications

• Budget impact analysis of triple therapy after failure of methotrexate for the treatment of rheumatoid arthritis in France – ISPOR Europe [weblink]
   

• Annual cost of patients undergoing a total knee replacement in France – ISPOR Europe [weblink]